Počet záznamů: 1

Micellar and antibody-targeted polymer therapeutics

  1. 1.
    0349044 - UMCH-V 2011 RIV DE eng J - Článek v odborném periodiku
    Etrych, Tomáš - Chytil, Petr - Kovář, Lubomír - Říhová, Blanka - Ulbrich, Karel
    Micellar and antibody-targeted polymer therapeutics.
    Macromolecular Symposia. Roč. 295, - (2010), s. 1-12 ISSN 1022-1360.
    [Prague Meetings on Macromolecules /73./ New Frontiers in Macromolecular Science: From Macromolecular Concepts of Living Matter to Polymers for Better Quality of Life. Prague, 05.07.2009-09.07.2009]
    Grant CEP: GA AV ČR IAA400500806; GA AV ČR IAAX00500803; GA MŠk 1M0505
    Výzkumný záměr: CEZ:AV0Z40500505; CEZ:AV0Z50200510
    Klíčová slova: doxorubicin * drug delivery systems * HPMA copolymers
    Kód oboru RIV: CD - Makromolekulární chemie

    Synthesis, physicochemical and some biological properties of new actively targeted antibody-containing and passively targeted micellar polymer - doxorubicin conjugates were investigated. Micellar HPMA-copolymer-based pharmaceuticals were prepared by self-assembly of copolymer–doxorubicin conjugates containing hydrophobic cholesterol ligands attached to the copolymer via hydrolytically degradable spacer. Synthesis of star antibody-targeted polymer conjugates takes advantage of reduction of disulfide bridges in antibody followed by conjugation with the semitelechelic copolymer.
    Trvalý link: http://hdl.handle.net/11104/0189386