HPMA-RGD Hydrogels Seeded with Mesenchymal Stem Cells Improve Functional Outcome in Chronic Spinal Cord Injury

0348921 - ÚEM 2011 RIV US eng J - Článek v odborném periodiku
Hejčl, Aleš - Šedý, Jiří - Kapcalová, Miroslava - Arboleda Toro, David - Amemori, Takashi - Lesný, Petr - Likavčanová, Katarína - Krumbholcová, Eva - Přádný, Martin - Michálek, Jiří - Burian, M. - Hájek, M. - Jendelová, Pavla - Syková, Eva
HPMA-RGD Hydrogels Seeded with Mesenchymal Stem Cells Improve Functional Outcome in Chronic Spinal Cord Injury.
Stem Cells and Development. Roč. 19, č. 10 (2010), s. 1535-1546. ISSN 1547-3287. E-ISSN 1557-8534
Grant CEP: GA MŠMT(CZ) LC554; GA AV ČR IAA500390902
Grant ostatní: GA ČR(CZ) GD309/08/H079; GA MZd(CZ) 1A8697; GA MŠk(CZ) 1M0538; EC FP6 project RESCUE(XE) LSHB-CT-2005-518233
Program: 1M
Výzkumný záměr: CEZ:AV0Z50390703; CEZ:AV0Z40500505
Klíčová slova: magnetic-resonance tracking * spinal cord injury * stem cells
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 4.791, rok: 2010

In the November issue of the Stem Cells and Development journal, Hejčl et al. published a paper HPMA-RGD hydrogels seeded with mesenchymal stem cells improve functional outcome in chronic spinal cord injury. In the paper the authors evaluate implantation of hydrogels based on hydroxypropylmethacrylamide with attached amino acids (HPMA-RGD) seeded with mesenchymal stem cells (MSCs; therapy group I) in the therapy of experimental chronic spinal cord injury (SCI) in rats. They compare this therapy with either implantation of HPMA-RGD hydrogels (therapy group II) or SCI only (control group). The results show that implantation of HPMA-RGD hydrogels seeded with MSCs led to improved motor and sensory function of the hindlimbs of the rats and reduced atrophy of the spinal cord after 6 months,
Trvalý link: http://hdl.handle.net/11104/0189308