Počet záznamů: 1

HPMA-RGD Hydrogels Seeded with Mesenchymal Stem Cells Improve Functional Outcome in Chronic Spinal Cord Injury

  1. 1.
    0348921 - UEM-P 2011 RIV US eng J - Článek v odborném periodiku
    Hejčl, Aleš - Šedý, Jiří - Kapcalová, Miroslava - Arboleda Toro, David - Amemori, Takashi - Lesný, Petr - Likavčanová, Katarína - Krumbholcová, Eva - Přádný, Martin - Michálek, Jiří - Burian, M. - Hájek, M. - Jendelová, Pavla - Syková, Eva
    HPMA-RGD Hydrogels Seeded with Mesenchymal Stem Cells Improve Functional Outcome in Chronic Spinal Cord Injury.
    Stem Cells and Development. Roč. 19, č. 10 (2010), s. 1535-1546 ISSN 1547-3287
    Grant CEP: GA MŠk(CZ) LC554; GA AV ČR IAA500390902
    Grant ostatní:GA ČR(CZ) GD309/08/H079; GA MZd(CZ) 1A8697; GA MŠk(CZ) 1M0538; EC FP6 project RESCUE(XE) LSHB-CT-2005-518233
    Program:1M
    Výzkumný záměr: CEZ:AV0Z50390703; CEZ:AV0Z40500505
    Klíčová slova: magnetic-resonance tracking * spinal cord injury * stem cells
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 4.791, rok: 2010

    In the November issue of the Stem Cells and Development journal, Hejčl et al. published a paper HPMA-RGD hydrogels seeded with mesenchymal stem cells improve functional outcome in chronic spinal cord injury. In the paper the authors evaluate implantation of hydrogels based on hydroxypropylmethacrylamide with attached amino acids (HPMA-RGD) seeded with mesenchymal stem cells (MSCs; therapy group I) in the therapy of experimental chronic spinal cord injury (SCI) in rats. They compare this therapy with either implantation of HPMA-RGD hydrogels (therapy group II) or SCI only (control group). The results show that implantation of HPMA-RGD hydrogels seeded with MSCs led to improved motor and sensory function of the hindlimbs of the rats and reduced atrophy of the spinal cord after 6 months,
    Trvalý link: http://hdl.handle.net/11104/0189308