Počet záznamů: 1

Long-circulating and passively tumor-targeted polymer-drug conjugates improve the efficacy and reduce the toxicity of radiochemotherapy

  1. 1.
    0348858 - UMCH-V 2011 RIV DE eng J - Článek v odborném periodiku
    Lammers, T. - Šubr, Vladimír - Ulbrich, Karel - Peschke, P. - Huber, P. E. - Hennink, W. E. - Storm, G. - Kiessling, F.
    Long-circulating and passively tumor-targeted polymer-drug conjugates improve the efficacy and reduce the toxicity of radiochemotherapy.
    Advanced Engineering Materials. Roč. 12, č. 9 (2010), B413-B421 ISSN 1438-1656
    Grant CEP: GA MŠk 1M0505
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: HPMA copolymers * targeting * tumor targeting
    Kód oboru RIV: EI - Biotechnologie a bionika
    Impakt faktor: 1.746, rok: 2010

    Using HPMA copolymers as a model drug carrier, and doxorubicin and gemcitabine as model drugs, we here show that long-circulating and passively tumor-targeted polymeric drug carriers interact synergistically with radiotherapy, with radiotherapy improving the tumor accumulation of the copolymers, and with the copolymers improving both the efficacy and the toxicity of radiochemotherapy. These findings indicate that “carrier-based radiochemotherapy” holds significant potential for improving the treatment of advanced solid malignancies.
    Trvalý link: http://hdl.handle.net/11104/0006063