Počet záznamů: 1

Intrinsic nitric oxide-stimulatory activity of lipoteichoic acids from different Gram-positive bacteria

  1. 1.
    0348719 - UEM-P 2011 RIV NL eng J - Článek v odborném periodiku
    Zídek, Zdeněk - Farghali, H. - Kmoníčková, Eva
    Intrinsic nitric oxide-stimulatory activity of lipoteichoic acids from different Gram-positive bacteria.
    Nitric Oxide-Biology and Chemistry. Roč. 23, č. 4 (2010), s. 300-310 ISSN 1089-8603
    Grant CEP: GA ČR GA305/08/0535
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: Lipoteichoic acid * Gram-positive bacteria * Nitric oxide
    Kód oboru RIV: FR - Farmakologie a lékárnická chemie
    Impakt faktor: 3.384, rok: 2010

    The cell wall of Gram-positive bacteria conain large amounts of lipoteichoic acid (LTA). We have found that LTA is endowed with immunostimulatory properties, the expression of which depends on its bacterial source. It has been demonstrated LTA shows positive response in Limulus amoebocyte assay (LAL), mimicking thus lipopolysaccharide (LPS) of Gram-negative bacteria. Similar to LPS, LTA binds to the antibiotics polymyxinB.
    Trvalý link: http://hdl.handle.net/11104/0189162