Počet záznamů: 1

Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles

  1. 1.
    0348175 - MBU-M 2011 RIV GB eng J - Článek v odborném periodiku
    Slámová, Kristýna - Marhol, Petr - Bezouška, K. - Lindkvist, L. - Hansen, G. S. - Křen, Vladimír - Jensen, H.H.
    Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles.
    Bioorganic and Medicinal Chemistry Letters. Roč. 20, č. 14 (2010), s. 4263-4265 ISSN 0960-894X
    Grant CEP: GA ČR GD305/09/H008
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: glycosidase inhibition * beta-N-Acetylhexosaminidase * N-Glycoside
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 2.661, rok: 2010

    Glycosyl 1,2,3-triazoles with a-D-gluco, b-D-gluco, a-D-galacto, b-D-galacto and b-2-acetamido-2-deoxygluco (GlcNAc) stereochemistry were prepared by reaction of the corresponding azides with vinyl acetate under microwave irradiation. The deprotected glucosyl and galactosyl triazoles did not display inhibitory activity against the tested glycosidases at 1 mM. Of the four fungal glycosidases evaluated, GlcNAc-triazole was found to be hydrolyzed by Talaromyces flavus CCF 2686 b-N-acetylhexosaminidase. β-GlcNActriazole was furthermore established to act as a strong ligand of rat and human natural killer cell activating receptors
    Trvalý link: http://hdl.handle.net/11104/0188772