Počet záznamů: 1

New in vitro reporter gene bioassays for screening of hormonal active compounds in the environment

  1. 1.
    0348168 - MBU-M 2011 RIV DE eng J - Článek v odborném periodiku
    Svobodová, Kateřina - Cajthaml, Tomáš
    New in vitro reporter gene bioassays for screening of hormonal active compounds in the environment.
    Applied Microbiology and Biotechnology. Roč. 88, č. 4 (2010), s. 839-847 ISSN 0175-7598
    Grant CEP: GA ČR GAP503/10/0408
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: endocrine disruptors * in vitro bioassays * reporter gene assays
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 3.280, rok: 2010

    Identification of chemicals with endocrinedisrupting activities in the past two decades has led to the need for sensitive assays for detection and monitoring of these activities in the environment. In vitro reporter gene assays represent a relatively fast and easy-to-perform method for detection of compounds that are able to bind to hormonal receptors and stimulate or silence their transactivation activity, thus interfering with the hormone signaling pathways. This paper reviews upgrades on reporter gene assays performed during the last decade
    Trvalý link: http://hdl.handle.net/11104/0188766