Počet záznamů: 1

Identification of Multiple Substrates of the StkP Ser/Thr Protein Kinase in Streptococcus pneumoniae

  1. 1.
    0348138 - MBU-M 2011 RIV US eng J - Článek v odborném periodiku
    Nováková, Linda - Bezoušková, Silvia - Pompach, Petr - Přenosilová, Lenka - Weiser, Jaroslav - Branny, Pavel
    Identification of Multiple Substrates of the StkP Ser/Thr Protein Kinase in Streptococcus pneumoniae.
    Journal of Bacteriology. Roč. 192, č. 14 (2010), s. 3629-3638 ISSN 0021-9193
    Grant CEP: GA ČR GA204/08/0783; GA AV ČR IAA600200801; GA ČR GP204/07/P082
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: GROUP-B STREPTOCOCCUS * EUKARYOTIC-TYPE * SERINE/THREONINE KINASE
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 3.726, rok: 2010

    The human pathogen Streptococcus pneumoniae encodes a single copy of a eukaryotic-like Ser/Thr protein kinase gene designated stkP. Previous studies demonstrated the pleiotropic role of the transmembrane protein kinase StkP in pneumococcal physiology. StkP regulates virulence, competence, and stress resistance and plays a role in the regulation of gene expression. In this study we identified three new substrates of StkP: the Mn-dependent inorganic pyrophosphatase PpaC, the hypothetical protein spr0334, and the cell division protein DivIVA. We showed that StkP activation and substrate recognition depend on the presence of a peptidoglycan-binding domain comprising four PASTA domain repeats. We found that StkP is regulated in a growth-dependent manner and likely senses intracellular peptidoglycan subunits present in the cell division septa
    Trvalý link: http://hdl.handle.net/11104/0188746