Počet záznamů: 1

Factors enhancing L-valine production by the growth-limited L-isoleucine auxotrophic strain Corynebacterium glutamicum D-eltailvA D-panB ilvNM13 (pECKAilvBNC)

  1. 1.
    0348125 - MBU-M 2011 RIV DE eng J - Článek v odborném periodiku
    Denina, I. - Paegle, L. - Prouza, Marek - Holátko, Jiří - Pátek, Miroslav - Nešvera, Jan - Ruklisha, M.
    Factors enhancing L-valine production by the growth-limited L-isoleucine auxotrophic strain Corynebacterium glutamicum D-eltailvA D-panB ilvNM13 (pECKAilvBNC).
    Journal of Industrial Microbiology & Biotechnology. Roč. 37, č. 7 (2010), s. 689-699 ISSN 1367-5435
    Grant CEP: GA ČR GC204/07/J012
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: Corynebacterium glutamicum * L-valine synthesis * Limited growth
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 2.416, rok: 2010

    The influence of stringent response on production of valine in recombinant strain of Corynebacterium glutamicum was tested. Increased production of valine was most probably caused by high activity of acetohydroxy acid synthase, the key enzyme of the biosynthesis of branched-chain amino acids. Positive effect of stringent response was shown in stationary growth phase due to maintaining high activity of acetohydroxy acid synthase and other enzymes of branched-chain amino acid biosynthesis
    Trvalý link: http://hdl.handle.net/11104/0188735