Počet záznamů: 1

N-(2-hydroxypropyl)methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin for cell-specific or passive tumour targeting. Synthesis by RAFT polymerisation and physicochemical characterisation

  1. 1.
    0347842 - UMCH-V 2011 RIV NL eng J - Článek v odborném periodiku
    Chytil, Petr - Etrych, Tomáš - Kříž, Jaroslav - Šubr, Vladimír - Ulbrich, Karel
    N-(2-hydroxypropyl)methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin for cell-specific or passive tumour targeting. Synthesis by RAFT polymerisation and physicochemical characterisation.
    European Journal of Pharmaceutical Sciences. Roč. 41, 3/4 (2010), s. 473-482 ISSN 0928-0987
    Grant CEP: GA AV ČR IAA400500806; GA AV ČR IAAX00500803
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: HPMA copolymers * drug carriers * RAFT polymerisation
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 3.291, rok: 2010

    Controlled RAFT polymerisation was used to prepare polymer–drug carriers based on HPMA copolymers, showing well-defined structure with narrow molecular weight distribution. The anticancer drug doxorubicin was bound to the polymeric carrier by hydrazone bond enabling pH-controlled release. RAFT polymerisation facilitated the synthesis of semitelechelic copolymers, which were used in the synthesis of monoclonal anti-CD20 antibody–polymer–drug conjugate and reductively degradable high-molecular-weight graft polymer–drug conjugate, designed for active or passive tumour targeting.
    Trvalý link: http://hdl.handle.net/11104/0006033