Počet záznamů: 1

Structural dynamics of the box C/D RNA Kink-Turn and its complex with proteins: The role of the A-minor 0 interaction, long-residency water bridges, and structural ion-binding sites revealed by molecular simulations

  1. 1.
    0347728 - BFU-R 2011 RIV US eng J - Článek v odborném periodiku
    Špačková, Naďa - Réblová, Kamila - Šponer, Jiří
    Structural dynamics of the box C/D RNA Kink-Turn and its complex with proteins: The role of the A-minor 0 interaction, long-residency water bridges, and structural ion-binding sites revealed by molecular simulations.
    Journal of Physical Chemistry B. Roč. 114, č. 32 (2010), s. 10581-10593 ISSN 1520-6106
    Grant CEP: GA MŠk(CZ) LC06030; GA AV ČR(CZ) KJB400040901; GA AV ČR(CZ) IAA400040802; GA ČR(CZ) GA203/09/1476
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: RNA-protein complex * molecular dynamics * kink-turn
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 3.603, rok: 2010

    The study is focused on investigation of Box C/D RNA Kink-Turn with two proteins: native archaeal L7ae protein and human 15.5 kDa protein. The simulations reveal structural details of the studied molecules on nanosecond time scale, i.e. structural dynamics of essential tertiary interaction within kink-turn, reduced kink-turn flexibility upon protein binding, structurally important water molecules and ion binding sites.
    Trvalý link: http://hdl.handle.net/11104/0006032