Počet záznamů: 1

Reduced UVB-induced corneal damage caused by reactive oxygen and nitrogen species and decreased changes in corneal optics after trehalose treatment

  1. 1.
    0347608 - UEM-P 2011 RIV ES eng J - Článek v odborném periodiku
    Čejková, Jitka - Čejka, Čestmír - Ardan, Taras - Širc, Jakub - Michálek, Jiří - Luyckx, J.
    Reduced UVB-induced corneal damage caused by reactive oxygen and nitrogen species and decreased changes in corneal optics after trehalose treatment.
    Histology and Histopathology. Roč. 25, č. 11 (2010), s. 1403-1416 ISSN 0213-3911
    Výzkumný záměr: CEZ:AV0Z50390512; CEZ:AV0Z40500505
    Klíčová slova: UVB rays * Rabbit cornea * Trehalose treatment
    Kód oboru RIV: FF - ORL, oftalmologie, stomatologie
    Impakt faktor: 2.502, rok: 2010

    Trehalose, a nonreducing disaccharide of glucose, is synthetized as a stress responsive factor when cells are exposed to various stress conditions. In UVB-irradiated cornea the effect of trehalose was compared with eyes treated with buffered saline during irradiation. Results show that trehalose significantly reduced oxidative damage of the cornea induced by UVB rays. Trehalose reduced changes of corneal optics, suppressed apoptosis of corneal cells and decreased the formation of peroxynitrite, the reaction product between superoxide and nitric oxide.
    Trvalý link: http://hdl.handle.net/11104/0188355