Počet záznamů: 1

NMDA receptor-dependent GABA(B) receptor internalization via CaMKII phosphorylation of serine 867 in GABA(B1)

  1. 1.
    0347602 - UEM-P 2011 RIV US eng J - Článek v odborném periodiku
    Guetg, N. - Aziz, S. A. - Holbro, N. - Tureček, Rostislav - Rose, T. - Seddik, R. - Gassmann, M. - Moes, S. - Jenoe, P. - Oertner, T.G. - Casanova, E. - Bettler, B.
    NMDA receptor-dependent GABA(B) receptor internalization via CaMKII phosphorylation of serine 867 in GABA(B1).
    Proceedings of the National Academy of Sciences of the United States of America. Roč. 107, č. 31 (2010), s. 13924-13929 ISSN 0027-8424
    Grant ostatní:EU(XE) LSHM-CT-2005-019055
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: gamma-aminobutyric acid * spines * trafficking
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 9.771, rok: 2010

    We have found that NMDA receptor activation promotes dynamin-dependent endocytosis of GABA(B) receptors by Ca2+/Calmodulin-dependent protein kinase II (CaMKII) mechanism. CaMKII associates with GABA(B) in vivo and phosphorylates serine 867 (S867) in the intracellular C terminus of the GABA(B1) subunit. Time-lapse two-photon imaging of organotypic hippocampal slices reveals that activation of NMDA receptors removes GABA(B) receptors within minutes from the surface of dendritic spines and shafts. NMDA-dependent GABA(B) internalization is represents a novel form of synaptic plasticity
    Trvalý link: http://hdl.handle.net/11104/0188349