Počet záznamů: 1

In position 7 l- and d-Tic-substituted oxytocin and deamino oxytocin: NMR study and conformational insights

  1. 1.
    0347360 - UOCHB-X 2011 RIV AT eng J - Článek v odborném periodiku
    Spyranti, Z. - Fragiadaki, M. - Magafa, V. - Borovičková, Lenka - Spyroulias, G. A. - Cordopatis, P. - Slaninová, Jiřina
    In position 7 l- and d-Tic-substituted oxytocin and deamino oxytocin: NMR study and conformational insights.
    Amino Acids. Roč. 39, č. 2 (2010), s. 539-548 ISSN 0939-4451
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: oxytocin analogues * deaminooxytocin * NMR
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 4.106, rok: 2010

    NMR study (NOESY, TOCSY, H-1-C-13 HSQC spectra) of analogues of oxytocin and deaminoocytocin having in position 7 L- or D-Tic is presented. The existence of both cis and trans configurations of the Cys(6)-D-Tic(7) bond is supported by observation of two sets of cross-peaks for H-1 and C-13 nuclei for most of the residues of the peptide not only in NOESY and TOCSY but also in H-1-C-13 HSQC spectra. The MS and HPLC indicate the presence of a single molecule/peptide, and NMR data thus suggest that this second set of peaks is due to the cis conformation.
    Trvalý link: http://hdl.handle.net/11104/0188154