Počet záznamů: 1

Cyclodextrin-Based Bimodal Fluorescence/MRI Contrast Agents: An Efficient Approach to Cellular Imaging

  1. 1.
    0347324 - UEM-P 2011 RIV DE eng J - Článek v odborném periodiku
    Kotková, Z. - Kotek, J. - Jirák, D. - Jendelová, Pavla - Herynek, V. - Berková, Z. - Hermann, P. - Lukeš, I.
    Cyclodextrin-Based Bimodal Fluorescence/MRI Contrast Agents: An Efficient Approach to Cellular Imaging.
    Chemistry - A European Journal. Roč. 16, č. 33 (2010), s. 10094-10102 ISSN 0947-6539
    Grant CEP: GA AV ČR(CZ) KAN201110651
    Grant ostatní: GA MŠk(CZ) MSM0021620857; EC FP6 project DiMI(XE) LSHB-CT-2005-512146; EC FP7 project ENCITE(XE) HEALTH-2007 A-201842; GA MŠk(CZ) GAUK 2007-B-Ch-132307
    Výzkumný záměr: CEZ:AV0Z50390703
    Klíčová slova: mesenchymal stem-cells * marrow stromal cells * water exchange-rate
    Kód oboru RIV: CA - Anorganická chemie
    Impakt faktor: 5.476, rok: 2010

    A novel bimodal fluorescence/MRI probe based on a cyclodextrin scaffold has been synthesized and characterized. The agent is not cytotoxic and is easily internalized into cells. The labelled cells can be visualized by MRI, as proved by the detection of individual labelled pancreatic islets. A fluorescence study performed on mesenchymal stem cells showed that the agent stays in the intracellular space for a long time.
    Trvalý link: http://hdl.handle.net/11104/0188126