Počet záznamů: 1

Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells

  1. 1.
    0347299 - BFU-R 2011 RIV IE eng J - Článek v odborném periodiku
    Hrubá, E. - Trilecová, L. - Marvanová, S. - Krčmář, P. - Vykopalová, L. - Milcová, Alena - Líbalová, Helena - Topinka, Jan - Staršíchová, Andrea - Souček, Karel - Vondráček, Jan - Machala, M.
    Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells.
    Toxicology Letters. Roč. 198, č. 3 (2010), s. 227-235 ISSN 0378-4274
    Grant ostatní: GA ČR(CZ) GA310/07/0961
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50390512; CEZ:AV0Z50390703
    Klíčová slova: prostate epithelial cells * DNA adducts * carcinogenesis
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 3.581, rok: 2010

    In the present study, we documented, for the first time, that although genotoxic PAHs produce significant levels of DNA adducts in the model of human prostate carcinoma cells, they do not activate the mechanisms leading to elimination of cells with significant DNA damage, presumably due to their failure to activate the p53-dependent DNA damage response.
    Trvalý link: http://hdl.handle.net/11104/0188104