Počet záznamů: 1

Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells

  1. 1.
    0347290 - BC-A 2011 RIV NL eng J - Článek v odborném periodiku
    Fialová, Anna - Cimburek, Zdeněk - Iezzi, G. - Kopecký, Jan
    Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells.
    Microbes and Infection. Roč. 12, č. 7 (2010), s. 580-585 ISSN 1286-4579
    Grant CEP: GA AV ČR IAA600960811
    Výzkumný záměr: CEZ:AV0Z60220518; CEZ:AV0Z50200510
    Klíčová slova: Tick-borne encephalitis virus * Dendritic cell * Tick saliva * Ixodes ricinus
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 2.726, rok: 2010

    Tick-borne encephalitis virus is an important human pathogen, naturally delivered into host skin via a tick bite. To examine the effects of the virus on dendritic cell biology, we cultured dendritic cells with two tick-borne encephalitis virus strains of different virulence in the presence of Ixodes ricinus tick saliva. Tick saliva treatment increased proportion of virus-infected cells, led to a decrease in virus-induced TNF-alpha and IL-6 production and to reduced virus-induced apoptosis. Our data indicate that tick saliva modulate virus-mediated alterations in dendritic cells, thus probably being involved in the early infection process in the host.
    Trvalý link: http://hdl.handle.net/11104/0188097