Počet záznamů: 1

Tumor necrosis factor α sensitizes spinal cord TRPV1 receptors to the endogenous agonist N-oleoyldopamine

  1. 1.
    0347210 - FGU-C 2011 RIV GB eng J - Článek v odborném periodiku
    Špicarová, Diana - Paleček, Jiří
    Tumor necrosis factor α sensitizes spinal cord TRPV1 receptors to the endogenous agonist N-oleoyldopamine.
    Journal of Neuroinflammation. Roč. 7, - (2010), s. 49-7 E-ISSN 1742-2094
    Grant CEP: GA MŠk(CZ) LC554; GA ČR GA305/09/1228
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: TNF * TRPV1 * pain
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 5.785, rok: 2010

    In our experiments the possible influence of TNFa on presynaptic spinal cord TRPV1 receptor function was investigated. Our results indicate that TNFa may have a significant impact on nociceptive signaling at the spinal cord level that could be mediated by increased responsiveness of presynaptic TRPV1 receptors to endogenous agonists. This could be of major importance, especially during pathological conditions, when increased levels of TNFa and TNFR are present in the spinal cord
    Trvalý link: http://hdl.handle.net/11104/0188038