Počet záznamů: 1

Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring PtII chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand

  1. 1.
    0347184 - BFU-R 2011 RIV US eng J - Článek v odborném periodiku
    Kašpárková, Jana - Suchánková, T. - Halámiková, Anna - Zerzánková, Lenka - Vrána, Oldřich - Margiotta, N. - Natile, G. - Brabec, Viktor
    Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring PtII chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand.
    Biochemical Pharmacology. Roč. 79, č. 4 (2010), s. 552-564 ISSN 0006-2952
    Grant CEP: GA MŠk(CZ) LC06030; GA MŠk(CZ) ME08017; GA MŠk(CZ) OC08003; GA AV ČR(CZ) 1QS500040581; GA AV ČR(CZ) KAN200200651; GA AV ČR(CZ) IAA400040803; GA AV ČR(CZ) GD301/09/H004
    Grant ostatní: GA MŠk(CZ) OC09018
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: DNA * platinum * cancer
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 4.889, rok: 2010

    This work describes a mechanistic study aimed at finding differences in those features of mechansim of activity of new antitumor PtII complex [PtCl2(cis-1,4-DACH)] (DACH = diaminocyclohexane) which are associated with its different biological effects in comparison with conventional cisplatin.
    Trvalý link: http://hdl.handle.net/11104/0188017