Počet záznamů: 1

Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling

  1. 1.
    0347149 - UMG-J 2011 RIV GB eng J - Článek v odborném periodiku
    Blažková, Hana - Krejčíková, Kateřina - Moudrý, Pavel - Frisan, T. - Hodný, Zdeněk - Bartek, Jiří
    Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling.
    Journal of Cellular and Molecular Medicine. Roč. 14, 1-2 (2009), s. 357-367 ISSN 1582-1838
    Grant CEP: GA AV ČR IAA500390501; GA ČR GA204/08/1418; GA ČR GA301/08/0353
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: cellular senescence * DNA damage response * bacterial toxins
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 5.228, rok: 2009

    Cytolethal distending toxins (CDT) are proteins produced and secreted by facultative pathogenic strains of gram-negative bacteria with potentially genotoxic effects. We found both normal and cancer human cells exposed to CDT, surviving the acute phase of intoxication by Haemophilus ducreyi CDT, possess the main hallmarks of cellular senescence including persistently activated DNA damage signalling, expansion of promyelocytic leukaemia nuclear compartment and induced expression of several cytokines (e.g. IL-6, IL-8 and IL-24). We conclude that analogous to oncogenic, oxidative and replicative stresses, bacterial toxins represent another pathophysiological stimulus that induces premature senescence. Thus, the activation of cellular senescence as the anticancer barrier, together with evidence of chromosomal defects reported here, support the emerging genotoxic and potentially oncogenic effects of this group of bacterial toxins, and warrant further research of their role in human disease.
    Trvalý link: http://hdl.handle.net/11104/0187989