Počet záznamů: 1

Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/beta-catenin signaling in the lens surface ectoderm

  1. 1.
    0347001 - UMG-J 2011 RIV US eng J - Článek v odborném periodiku
    Machoň, Ondřej - Krešlová, Jana - Růžičková, Jana - Vacík, Tomáš - Klímová, Lucie - Fujimura, Naoko - Láchová, Jitka - Kozmik, Zbyněk
    Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/beta-catenin signaling in the lens surface ectoderm.
    Genesis. Roč. 48, č. 2 (2010), s. 86-95 ISSN 1526-954X
    Grant CEP: GA ČR GA204/08/1618; GA MŠk(CZ) 1M0520
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: Wnt, Pax6 * lens * eye
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 2.395, rok: 2010

    Lens formation in mouse is critically dependent on proper development of the retinal neuroectoderm that is located close beneath the head surface ectoderm. Signaling from the prospective retina triggers lens-specific gene expression in the surface-ectoderm. Supression of canonical Wnt/β-catenin signaling in the surface ectoderm is one of the prerequisites for lens development because, as we show here, ectopic Wnt activation in the retina and lens abrogates lens formation. Wnt inhibiton is mediated by signals coming from the retina but its exact mechanism is unknown. We show that Pax6 directly controls expression of several Wnt inhibitors such as Sfrp1, Sfrp2, and Dkk1 in the presumptive lens. In accordance, absence of Pax6 function leads to aberrant canonical Wnt activity in the presumptive lens that subsequently impairs lens development. Thus Pax6 is required for down-regulation of canonical Wnt signaling in the presumptive lens ectoderm.
    Trvalý link: http://hdl.handle.net/11104/0187879
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