Počet záznamů: 1

P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes

  1. 1.
    0346838 - UMG-J 2011 RIV US eng J - Článek v odborném periodiku
    Flemr, Matyáš - Ma, J. - Schultz, R. M. - Svoboda, Petr
    P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes.
    Biology of Reproduction. Roč. 82, č. 5 (2010), s. 1008-1017 ISSN 0006-3363
    Grant CEP: GA MŠk ME09039
    Grant ostatní: EMBO SDIG(DE) project 1483
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: oocyte * mRNA * cortex
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 3.870, rok: 2010

    P-bodies are centers of mRNA metabolism, where meet pathways linked to mRNA silencing and degradation. So far, P-bodies were found in all examined mammalian cells.Here, we show an unexpected and important discovery that P-bodies disappear from oocztes at the beginning of their growth phase and appear again only in the early embryo. P-body decay likely reflects the requirement stabiliyation and storage of maternal mRNAs, which will govern development until the zygotc expression takes over. In addition, we were the first to show that stored maternal mRNAs do not have a homogeneous distribution. Instead, they localize to the periphery – cortex.
    Trvalý link: http://hdl.handle.net/11104/0187756
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