Počet záznamů: 1

A new type of membrane raft-like microdomains and their possible involvement in TCR signaling

  1. 1.
    0346793 - UMG-J 2011 RIV US eng J - Článek v odborném periodiku
    Otáhal, Pavel - Angelisová, Pavla - Hrdinka, Matouš - Brdička, Tomáš - Novák, Petr - Drbal, Karel - Hořejší, Václav
    A new type of membrane raft-like microdomains and their possible involvement in TCR signaling.
    Journal of Immunology. Roč. 184, č. 7 (2010), s. 3689-3696 ISSN 0022-1767
    Výzkumný záměr: CEZ:AV0Z50520514; CEZ:AV0Z50200510
    Klíčová slova: membrane rafts * LAT * T-receptor
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 5.745, rok: 2010

    One of the key signaling molecules present in T cell detergent-resistant membrane domains (DRMs) derived from membrane rafts is the transmembrane adaptor protein LAT (linker for activation of T cells). In contrast to previous results, a recent study demonstrated that a LAT construct not present in the buoyant DRMs is fully able to support TCR signaling and development of T cells in vivo. This finding caused doubts about the real physiological role of rafts in TCR signaling. In this study, we demonstrate that these results can be explained by the existence of a novel type of membrane raft-like microdomains, containing a number of membrane molecules. At a moderate level of expression, LAT supported TCR signaling more efficiently than constructs targeted to the microdomains producing heavy DRMs or to nonraft membrane. We suggest that different types of membrane microdomains provide environments regulating the functional efficiencies of signaling molecules present therein.
    Trvalý link: http://hdl.handle.net/11104/0187721
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