Počet záznamů: 1

Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro

  1. 1.
    0346777 - BTO-N 2011 RIV US eng J - Článek v odborném periodiku
    Čtrnáctá, Vlasta - Fritzler, J. M. - Šurínová, M. - Hrdý, I. - Zhu, G. - Stejskal, F.
    Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro.
    Experimental Parasitology. Roč. 126, č. 2 (2010), s. 113-116 ISSN 0014-4894
    Výzkumný záměr: CEZ:AV0Z50520701
    Klíčová slova: S-adenosylhomocysteine hydrolase * D-eritadenine * (S)-DHPA
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 1.869, rok: 2010

    D-eritadenine and (S)-DHPA are aliphatic adenosine analogues known to target S-adenosylhomocysteine hydrolase (SAHH) and potent antiviral compounds. In the present study, we demonstrate that these two compounds also display efficacy against recombinant SAHH enzyme of the protozoan parasite Cryptosporidium parvum, as well as inhibition of parasite growth in vitro. Our data confirm that SAHH could serve as a rational drug target in cryptosporidial infection and antiviral adenosine analogues are potential candidates for drug development against cryptosporidiosis
    Trvalý link: http://hdl.handle.net/11104/0187708