Počet záznamů: 1

The chicken Z chromosome is enriched for genes with preferential expression in ovarian somatic cells

  1. 1.
    0346754 - UMG-J 2012 RIV US eng J - Článek v odborném periodiku
    Mořkovský, L. - Storchová, R. - Plachý, Jiří - Ivánek, Robert - Divina, Petr - Hejnar, Jiří
    The chicken Z chromosome is enriched for genes with preferential expression in ovarian somatic cells.
    Journal of Molecular Evolution. Roč. 70, č. 2 (2010), s. 129-136 ISSN 0022-2844
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: Z chromosome * meiotic sex chromosome inactivation * sexual antagonisms
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 2.311, rok: 2010

    Over- or under-representation of sexually antagonistic mutations on avian X and Z chromosomes depends, in theory, on their average dominance coefficients. These coefficients, however, remain to be characterized. To elucidate the role of sexually antagonistic selection in the evolution of Z chromosome gene content in chicken, we analyzed publicly available microarray data from several somatic tissues as well as somatic and germ cells of the ovary. We found that the Z chromosome is enriched for genes showing preferential expression in ovarian somatic cells, but not for genes with preferential expression in primary oocytes or non-sex-specific somatic tissues. Our results suggest that sexual antagonism leads to higher abundance of female-benefit alleles on the Z chromosome. Our results are consistent with findings in mammals and indicate that recessive rather than dominant sexually antagonistic mutations shape the gene content of the X and Z chromosomes.
    Trvalý link: http://hdl.handle.net/11104/0187690
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