Počet záznamů: 1

Polyoxazoline thermoresponsive micelles as radionuclide delivery systems

  1. 1.
    0346570 - UMCH-V 2011 RIV DE eng J - Článek v odborném periodiku
    Hrubý, Martin - Filippov, Sergey K. - Pánek, Jiří - Nováková, Michaela - Macková, Hana - Kučka, Jan - Větvička, David - Ulbrich, Karel
    Polyoxazoline thermoresponsive micelles as radionuclide delivery systems.
    Macromolecular Bioscience. Roč. 10, č. 8 (2010), s. 916-924 ISSN 1616-5187
    Grant CEP: GA AV ČR KAN200200651; GA ČR GA202/09/2078; GA MŠk 1M0505; GA ČR GPP207/10/P054
    Výzkumný záměr: CEZ:AV0Z40500505; CEZ:AV0Z50200510
    Klíčová slova: micelles * drug delivery systems * thermoresponsive polymers
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 3.458, rok: 2010

    Thermoresponsive polymer micelles are promising drug and radionuclide carriers with a strong passive targeting effect into solid tumors. We have synthesized ABA triblock copolymers poly[2-methyl-2-oxazoline-block-(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline)-block-2-methyl-2-oxazoline]. These polymers are molecularly dissolved in aqueous millieu below the cloud point temperature (CPT) of the thermoresponsive central block and above CPT form polymer micelles at CMC 5–10 × 10−5 g • mL−1 with diameter ≈200 nm. The phenolic moiety introduced into the copolymer allowed radionuclide labeling with iodine-125 ongoing in good yield with sufficient in vitro stability under model conditions.
    Trvalý link: http://hdl.handle.net/11104/0005988