Počet záznamů: 1

Cathepsins B1 and B2 in the neuropathogenic schistosome Trichobilharzia regenti: distinct gene expression profiles and presumptive roles throughout the life cycle

  1. 1.
    0346460 - UBO-W 2011 RIV DE eng J - Článek v odborném periodiku
    Dolečková, K. - Albrecht, Tomáš - Mikeš, L. - Horák, P.
    Cathepsins B1 and B2 in the neuropathogenic schistosome Trichobilharzia regenti: distinct gene expression profiles and presumptive roles throughout the life cycle.
    Parasitology Research. Roč. 107, č. 3 (2010), s. 751-755 ISSN 0932-0113
    Grant CEP: GA MŠk LC06073
    Výzkumný záměr: CEZ:AV0Z60930519
    Klíčová slova: Cathepsin * Schistosome * Trichobilharzia * Helminth * Neuropathogen
    Kód oboru RIV: GJ - Choroby a škůdci zvířat, veterinární medicína
    Impakt faktor: 1.812, rok: 2010

    Real-time polymerase chain reaction was used to characterize the temporal distribution of transcripts of two cathepsins in different developmental stages of Trichobilharzia regenti: cathepsin B1 originally described from the gut lumen of schistosomula with presumptive role in nutrient digestion and cathepsin B2 originally found in penetration glands of cercariae with probable involvement in invasion of the final host. The mRNA expression profiles clearly show distinct expression of cathepsins B1 and B2 during the development from eggs to cercariae. In the case of both cathepsins, the highest level of transcription was detected in intravertebrate stages.
    Trvalý link: http://hdl.handle.net/11104/0187484