Počet záznamů: 1

Guanine–aspartic acid interactions probed with IR–UV resonance Spectroscopy

  1. 1.
    0346457 - UOCHB-X 2011 RIV GB eng J - Článek v odborném periodiku
    Crews, B. O. - Abo-Riziq, A. - Pluháčková, Kristýna - Thompson, P. - Hill, G. - Hobza, Pavel - de Vries, M. S.
    Guanine–aspartic acid interactions probed with IR–UV resonance Spectroscopy.
    Physical Chemistry Chemical Physics. Roč. 12, č. 14 (2010), s. 3597-3605 ISSN 1463-9076
    Grant CEP: GA MŠk LC512; GA AV ČR IAA400550510
    Grant ostatní: NSF(US) CHE-0911564
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: double resonance spectroscopy * correlated ab initio calculations * guanine-aspartic acid complexes
    Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
    Impakt faktor: 3.454, rok: 2010

    Double resonance spectroscopy of clusters of guanine with aspartic acid reveals geometries similar to patterns exhibited in DNA base pairs. In the spectral region of 32 800 cm-1 to 35 500 cm-1 we observe five isomers of guanine–aspartic acid clusters and assign their structures based on IR–UV hole-burning spectra and wave function theory calculations at the MP2/cc-pVDZ and MP2/cc-pVTZ levels. Three of the isomers are similar, assigned to structures containing three hydrogen bonds and 9-enolguanine. We assign the fourth isomer to a structure containing a 9-keto tautomer of guanine and forming a triply bonded structure similar to a base pairing interaction. The fifth isomer dissociates with proton transfer upon excitation or ionization. This is the first set of experiments and high-level ab initio calculations of the isolated, microscopic interactions of an amino acid and a nucleobase, the building blocks of nucleic acids and proteins.
    Trvalý link: http://hdl.handle.net/11104/0187481