Počet záznamů: 1

Analysis of Amaryllidaceae Alkaloids from Zephyranthes robusta by GC-MS and Their Cholinesterase Activity

  1. 1.
    0346356 - UOCHB-X 2011 RIV US eng J - Článek v odborném periodiku
    Cahlíková, L. - Kulhánková, A. - Urbanová, Klára - Valterová, Irena - Macáková, K. - Kuneš, J.
    Analysis of Amaryllidaceae Alkaloids from Zephyranthes robusta by GC-MS and Their Cholinesterase Activity.
    Natural Product Communications. Roč. 5, č. 8 (2010), s. 1201-1204 ISSN 1934-578X
    Grant ostatní: GA UK(CZ) 122309
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: Zephyranthes robusta * Amaryllidaceae * GC/MS * acetylcholinesterase * butyrylcholinesterase
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 0.894, rok: 2010
    www.naturalproduct.us

    From the bulbs of Zephyranthes robusta Baker (Amaryllidaceae), seven known compounds, belonging to four structural types of Amaryllidaceae alkaloids, were identified and quantified by GC-MS. The alkaloid extract from the bulbs showed promising acetylcholinesterase and butyrylcholinesterase inhibitory activities against HuAChE (IC50 = 35.9 ± 3.5 μg/mL) and HuBuChE (IC50 = 190.9 ± 8.2 μg/mL).
    Trvalý link: http://hdl.handle.net/11104/0187406