Počet záznamů: 1

Single- and Double-Headed Chemical Probes for Detection of Active Cathepsin D in a Cancer Cell Proteome

  1. 1.
    0346346 - UOCHB-X 2011 RIV DE eng J - Článek v odborném periodiku
    Nussbaumerová, Martina - Srp, Jaroslav - Máša, Martin - Hradilek, Martin - Šanda, Miloslav - Reiniš, Milan - Horn, Martin - Mareš, Michael
    Single- and Double-Headed Chemical Probes for Detection of Active Cathepsin D in a Cancer Cell Proteome.
    Chembiochem. Roč. 11, č. 11 (2010), s. 1538-1541 ISSN 1439-4227
    Grant CEP: GA AV ČR IAA400550705
    Výzkumný záměr: CEZ:AV0Z40550506; CEZ:AV0Z50520514
    Klíčová slova: cathepsin D * cancer * activity-based probes
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 3.945, rok: 2010

    We present the design of activity-based probes for cathepsins D that are effective in a complex proteome. The probes consist of a binding module with a statin-containing peptidic core, a warhead module bearing a photoreactive group, and a reporter tag. The fluorescent and biotin tags make the probes a powerful tool for a wide range of "in-gel" and "on-blot" proteomic applications.
    Trvalý link: http://hdl.handle.net/11104/0187399