Počet záznamů: 1

Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy

  1. 1.
    0345886 - UOCHB-X 2011 RIV NL eng J - Článek v odborném periodiku
    Keough, D. T. - Hocková, Dana - Krečmerová, Marcela - Česnek, Michal - Holý, Antonín - Naesens, L. - Brereton, I. M. - Winzor, D. J. - de Jersey, J. - Guddat, L. W.
    Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy.
    Molecular and Biochemical Parasitology. Roč. 173, č. 2 (2010), s. 165-169 ISSN 0166-6851
    Grant CEP: GA MŠk 1M0508
    Grant ostatní: National Health and Medical Research Council(AU) 569703
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: acyclic nucleoside phosphonates * Plasmodium vivax * 6-oxopurine phosphoribosyltransferase
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.875, rok: 2010

    For protozoan parasites, 6-oxopurine phosphoribosyltransferases (PRTases) provide the only metabolic pathway to synthesize the purine nucleoside monophosphates essential for DNA/RNA production. This enzyme from Plasmodium vivax was cloned, expressed and purified and its properties compared with those of the corresponding enzymes from human and P. falciparum. Several acyclic nucleoside phosphonates were evaluated as inhibitors of PvHGPRT giving Ki values as low as 0.5 .mu.M.
    Trvalý link: http://hdl.handle.net/11104/0187064