Počet záznamů: 1

Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors

  1. 1.
    0345730 - UOCHB-X 2011 RIV GB eng J - Článek v odborném periodiku
    Šála, Michal - De Palma, A. M. - Hřebabecký, Hubert - Nencka, Radim - Dračínský, Martin - Leyssen, P. - Neyts, J. - Holý, Antonín
    Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors.
    Bioorganic & Medicinal Chemistry. Roč. 18, č. 12 (2010), s. 4374-4384 ISSN 0968-0896
    Grant CEP: GA MŠk 1M0508
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: 6-chloropurine * coxsackievirus B3 * bicyclo[2.2.1]heptane
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.978, rok: 2010

    Novel class of coxsackievirus inhibitors derived from a bicyclo[2.2.1]heptane was synthetised and target compounds were tested for antiviral activity against coxsackievirus B3. Most analogues showed activity in the low micromolar range with minimal cytotoxicity.
    Trvalý link: http://hdl.handle.net/11104/0186933