Počet záznamů: 1

Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles

  1. 1.
    0345370 - BFU-R 2011 RIV US eng J - Článek v odborném periodiku
    Zerzánková, Lenka - Suchánková, T. - Vrána, Oldřich - Farrell, N.P. - Brabec, Viktor
    Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles.
    Biochemical Pharmacology. Roč. 79, č. 2 (2010), s. 112-121 ISSN 0006-2952
    Grant CEP: GA MŠk(CZ) LC06030; GA MŠk(CZ) ME08017; GA MŠk(CZ) OC08003; GA AV ČR(CZ) 1QS500040581; GA AV ČR(CZ) KAN200200651
    Grant ostatní:GA MŠk(CZ) OC09018
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: antitumor * dinuclear platinum complex * DNA damage
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 4.889, rok: 2010

    A detailed biochemical and molecular biophysics study of the molecular mechanism of action of a new dinuclear PtII complex [{PtCl(1,2-diaminocyclohexane)}2-my-Y]4+, resistant to decomposition by sulfur nucleophiles, was reported herein. The results show that this complex exhibits promising antitumor features as its DNA adducts can largely escape repair and inhibit very effectively transcription.
    Trvalý link: http://hdl.handle.net/11104/0186655