Počet záznamů: 1
The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance
0345074 - FGU-C 2011 RIV US eng J - Článek v odborném periodiku
Atanur, S. S. - Birol, I. - Guryev, V. - Hirst, M. - Hummel, O. - Morrissey, C. - Behmoaras, J. - Fernandez-Suarez, X.M. - Johnson, M. D. - McLaren, W. M. - Patone, G. - Petretto, E. - Plessy, Ch. - Rockland, K. S. - Rockland, Ch. - Saar, K. - Zhao, Y. - Carninci, P. - Flicek, P. - Kurtz, T. - Cuppen, E. - Pravenec, Michal - Hubner, N. - Jones, S. J. M. - Birney, E. - Aitman, T. J.
The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance.
Genome Research. Roč. 20, č. 6 (2010), s. 791-803 ISSN 1088-9051
Grant CEP: GA MŠk(CZ) 1M0520
Grant ostatní:EC(XE) LSHG-CT-2005-019015; HHMI(US) HHMI; Transatlantic network of excellence(US) Foundation Leducq
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: spontaneously hypertensive rat * genome sequence * genetics
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 13.588, rok: 2010
The spontaneously hypertensive rat (SHR) is the most widely studied animal model of hypertension. Scores of SHR quantitative loci (QTLs) have been mapped for hypertension and other phenotypes. We have sequenced the SHR/OlaIpcv genome at 10.7-fold coverage by paired-end sequencing on the Illumina platform. This near complete catalog of genomic differences between two extensively studied rat strains provides the starting point for complete elucidation, at the molecular level, of the physiological and pathophysiological phenotypic differences between individuals from these strains
Trvalý link: http://hdl.handle.net/11104/0186428