Počet záznamů: 1

The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance

  1. 1.
    0345074 - FGU-C 2011 RIV US eng J - Článek v odborném periodiku
    Atanur, S. S. - Birol, I. - Guryev, V. - Hirst, M. - Hummel, O. - Morrissey, C. - Behmoaras, J. - Fernandez-Suarez, X.M. - Johnson, M. D. - McLaren, W. M. - Patone, G. - Petretto, E. - Plessy, Ch. - Rockland, K. S. - Rockland, Ch. - Saar, K. - Zhao, Y. - Carninci, P. - Flicek, P. - Kurtz, T. - Cuppen, E. - Pravenec, Michal - Hubner, N. - Jones, S. J. M. - Birney, E. - Aitman, T. J.
    The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance.
    Genome Research. Roč. 20, č. 6 (2010), s. 791-803 ISSN 1088-9051
    Grant CEP: GA MŠk(CZ) 1M0520
    Grant ostatní: EC(XE) LSHG-CT-2005-019015; HHMI(US) HHMI; Transatlantic network of excellence(US) Foundation Leducq
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: spontaneously hypertensive rat * genome sequence * genetics
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 13.588, rok: 2010

    The spontaneously hypertensive rat (SHR) is the most widely studied animal model of hypertension. Scores of SHR quantitative loci (QTLs) have been mapped for hypertension and other phenotypes. We have sequenced the SHR/OlaIpcv genome at 10.7-fold coverage by paired-end sequencing on the Illumina platform. This near complete catalog of genomic differences between two extensively studied rat strains provides the starting point for complete elucidation, at the molecular level, of the physiological and pathophysiological phenotypic differences between individuals from these strains
    Trvalý link: http://hdl.handle.net/11104/0186428