Počet záznamů: 1

Dynamics of the base of ribosomal A-site finger revealed by molecular dynamics simulations and Cryo-EM

  1. 1.
    0344070 - BFU-R 2011 RIV GB eng J - Článek v odborném periodiku
    Réblová, Kamila - Rázga, Filip - Li, W. - Gao, H. - Frank, J. - Šponer, Jiří
    Dynamics of the base of ribosomal A-site finger revealed by molecular dynamics simulations and Cryo-EM.
    Nucleic Acids Research. Roč. 38, č. 4 (2010), s. 1325-1340 ISSN 0305-1048
    Grant CEP: GA MŠk(CZ) LC06030; GA AV ČR(CZ) KJB400040901; GA AV ČR(CZ) 1QS500040581; GA AV ČR(CZ) IAA400040802; GA ČR(CZ) GA203/09/1476
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: molecular dynamics * Cryo-electron microscopy * RNA
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 7.836, rok: 2010

    We carried out molecular dynamics simulations of the base of the A-site finger from archaeal and three bacterial large subunits. The study showed that despite noticeable differences in the secondary structures, the studied segments adopt almost identical fold and exhibit similar stochastic fluctuations. Geometries of segments from the simulations correspond to structures obtained by Cryo-electron microscopy.
    Trvalý link: http://hdl.handle.net/11104/0186380