Počet záznamů: 1

Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat

  1. 1.
    0344049 - FGU-C 2011 RIV GB eng J - Článek v odborném periodiku
    Jirout, M. L. - Friese, R. S. - Mahapatra, N. R. - Mahata, M. - Taupenot, L. - Mahata, S. K. - Křen, V. - Zídek, Václav - Fischer, J. - Maatz, H. - Ziegler, M. G. - Pravenec, Michal - Hubner, N. - Aitman, T. J. - Schork, N. J. - O´Connor, D. T.
    Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat.
    Human Molecular Genetics. Roč. 19, č. 13 (2010), s. 2567-2580 ISSN 0964-6906
    Grant CEP: GA AV ČR(CZ) IAA500110604
    Grant ostatní: HHMI(US) HHMI
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: spontaneously hypertensive rat * catecholamines * blood pressure
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 8.058, rok: 2010

    We identified cis-acting eQTLs for Dbh, Pnmt (catecholamine biosynthesis) and Vamp1 (catecholamine secretion); enzymatic activities of Dbh and Pnmt paralleled transcripts, with pQTLs for activities mirroring eQTLs. We also detected trans-regulated expression of Vmat1 and Chga (both involved in catecholamine storage), with co-localization of these trans-eQTLs to the Pnmt locus. The finding of such cis- and trans-QTLs at an age before the onset of frank hypertension suggests that these heritable changes in biosynthetic enzyme expression represent primary genetic mechanisms for regulation of catecholamine action and blood pressure control in this widely studied model of hypertension
    Trvalý link: http://hdl.handle.net/11104/0186368