Počet záznamů: 1

beta-1,2,3-Triazolyl-Nucleosides as Nicotinamide Riboside Mimics

  1. 1.
    0344010 - UEB-Q 2011 RIV US eng J - Článek v odborném periodiku
    Amigues, E.J. - Armstrong, E. - Dvořáková, Marcela - Migaud, M.E. - Huang, M.
    beta-1,2,3-Triazolyl-Nucleosides as Nicotinamide Riboside Mimics.
    Nucleosides Nucleotides & Nucleic Acids. Roč. 28, č. 3 (2009), s. 238-259 ISSN 1525-7770
    Výzkumný záměr: CEZ:AV0Z50380511
    Klíčová slova: Nucleoside * nucleotide * sirtuin
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 0.768, rok: 2009

    The synthesis of a series of pyridine- and piperidine-substituted 1,2,3-triazolides linked to a riboside moiety is described. The presence of a triazolide substituent on the pyridine moiety permitted the facile reduction of the latter under mild hydrogenation conditions. These analogues were modelled as to define their similarity to nicotinamide riboside and quantify their ability to bind NAD-dependent protein deacetylases.
    Trvalý link: http://hdl.handle.net/11104/0186347