Počet záznamů: 1

The interactions of the C-terminal region of the TRPC6 channel with calmodulin

  1. 1.
    0343356 - FGU-C 2011 RIV GB eng J - Článek v odborném periodiku
    Friedlová, Eliška - Gryčová, Lenka - Holakovská, Blanka - Šilhán, Jan - Janoušková, Hana - Šulc, Miroslav - Obšilová, Veronika - Obšil, T. - Teisinger, Jan
    The interactions of the C-terminal region of the TRPC6 channel with calmodulin.
    Neurochemistry International. Roč. 56, č. 2 (2010), s. 363-366 ISSN 0197-0186
    Grant CEP: GA AV ČR(CZ) IAA600110701; GA ČR(CZ) GA303/07/0915; GA ČR(CZ) GD305/08/H037; GA MŠk(CZ) LC554
    Výzkumný záměr: CEZ:AV0Z50110509; CEZ:AV0Z50200510
    Klíčová slova: TRPC6 * calmodulin * fluorescence anisotropy
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 3.601, rok: 2010

    TRPC6 is a non-selective cation channel which modulates the calcium level in eukaryotic cells in response to external signals. One calmodulin (CaM) binding site was identified within the C-tail of TRPC6. The aim of this study is to map in detail the CaM and inositol (1,4,5)-triphosphate receptor binding (CIRB) domain in the C-terminal region of mouse TRPC6 that is capable of interacting with CaM using in vitro binding assays
    Trvalý link: http://hdl.handle.net/11104/0185855