Počet záznamů: 1

Alternative synthesis of 9-{3-[(diisopropoxyphosphoryl)-methoxy]-2-hydroxypropyl}adenine and its free phosphonates substituted at the C-8 position of purine base

  1. 1.
    0343322 - UOCHB-X 2011 RIV CZ eng J - Článek v odborném periodiku
    Janeba, Zlatko - Masojídková, Milena - Holý, Antonín
    Alternative synthesis of 9-{3-[(diisopropoxyphosphoryl)-methoxy]-2-hydroxypropyl}adenine and its free phosphonates substituted at the C-8 position of purine base.
    Collection of Czechoslovak Chemical Communications. Roč. 75, č. 3 (2010), s. 371-381 ISSN 0010-0765
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: acyclic nucleoside phosphonates * HPMPA * nucleophilic substitution * intramolecular cyclization
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 0.853, rok: 2010

    New approach to 9-[2-hydroxy-3-(phosphonomethoxy)propyl]adenine (iso-HPMPA) is described and a series of iso-HPMPA derivatives substituted at the C-8 position of the purine ring was prepared. Synthesis of the key alkylating agent was developed starting from allyl alcohol.
    Trvalý link: http://hdl.handle.net/11104/0185828