Počet záznamů: 1

The Acyclic 2,4-Diaminopyrimidine Nucleoside Phosphonate Acts as a Purine Mimetic in HIV-1 Reverse Transcriptase DNA Polymerization

  1. 1.
    0343318 - UOCHB-X 2011 RIV US eng J - Článek v odborném periodiku
    Herman, B. D. - Votruba, Ivan - Holý, Antonín - Sluis-Cremer, N. - Balzarini, J.
    The Acyclic 2,4-Diaminopyrimidine Nucleoside Phosphonate Acts as a Purine Mimetic in HIV-1 Reverse Transcriptase DNA Polymerization.
    Journal of Biological Chemistry. Roč. 285, č. 16 (2010), s. 12101-12108 ISSN 0021-9258
    Grant ostatní: NIH(US) R01 AI81571; KU Leuven(BE) GOA Kredit 05/19
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: acyclic nucleotide analogue * purine open ring * HIV-1 RT * antiviral * antimetabolite
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 5.328, rok: 2010

    HIV-1 RT recognizes diphosphate of the acyclic pyrimidine nucleoside phosphonate (ANP) phosphonylmethoxyethoxydiaminopyrimidine (PMEO-DAPym) as purine nucleotide analogue. Molecular modeling demonstrates that PMEO-DAPym-pp fits into the active site of HIV-1 RT and incorporates opposite to thymine (in DNA). The data revealed that PMEODAPym represents the prototype compound of a novel class of pyrimidine acyclic nucleoside phosphonates and should form the rational basis for the design and development of novel purine nucleo(s)(t)ide mimetics as potential antiviral or antimetabolic agents.
    Trvalý link: http://hdl.handle.net/11104/0185824