Počet záznamů: 1

Simvastatin: structure solution of two new low-temperature phases from synchrotron powder diffraction and ss-NMR

  1. 1.
    0343202 - UMCH-V 2011 RIV US eng J - Článek v odborném periodiku
    Hušák, M. - Kratochvíl, B. - Jegorov, A. - Brus, Jiří - Maixner, J. - Rohlíček, J.
    Simvastatin: structure solution of two new low-temperature phases from synchrotron powder diffraction and ss-NMR.
    Structural Chemistry. Roč. 21, č. 3 (2010), s. 511-518 ISSN 1040-0400
    Grant CEP: GA AV ČR IAA400500602; GA MŠk 2B08021
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: crystal structure * simvastatin * powder diffraction
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 1.727, rok: 2010

    Simvastatin is an active pharmaceutical ingredient generally used for the treatment of hypercholesterolemia. In addition to the already known room-temperature structure of simvastatin, two new low-temperature polymorphs were found with the phase transition at 272 and 232 K. The main structural differences between these three polymorphs consist in the side-chains conformation. The observed phase transformations are fully reversible. The structures of the polymorphs were studied by the powder diffraction based on synchrotron radiation as well as by solid-state NMR spectroscopy.
    Trvalý link: http://hdl.handle.net/11104/0005900