Počet záznamů: 1

Remodelling of living bone induced by dynamic loading and drug delivery—Numerical modelling and clinical treatment

  1. 1.
    0343142 - UT-L 2011 RIV NL eng J - Článek v odborném periodiku
    Maršík, František - Klika, Václav - Chlup, Hynek
    Remodelling of living bone induced by dynamic loading and drug delivery—Numerical modelling and clinical treatment.
    Mathematics and Computers in Simulation. Roč. 80, č. 6 (2010), s. 1278-1288 ISSN 0378-4754
    Grant CEP: GA ČR GA106/03/1073; GA ČR(CZ) GA106/08/0557
    Grant ostatní: GA ČR(CZ) GA201/06/0352
    Výzkumný záměr: CEZ:AV0Z20760514
    Klíčová slova: bone remodelling * chemical kinetics * biochemical model
    Kód oboru RIV: BJ - Termodynamika
    Impakt faktor: 0.812, rok: 2010
    http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6V0T-4VT1FYX-1-1&_cdi=5655&_user=640952&_pii=S0378475409000664&_origin=search&_coverDate=02%2F28%2F2010&_sk=999199993&view=c&wchp=dGLzVlz-zSkzV&md5=efaf801defe31154a1c6c44a9c5edef0&ie=/sdarticle.pdf http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6V0T-4VT1FYX-1-1&_cdi=5655&_user=640952&_pii=S0378475409000664&_origin=search&_coverDate=02%2F28%2F2010&_sk=999199993&view=c&wchp=dGLzVlz-zSkzV&md5=efaf801defe31154a1c6c44a9c5edef0&ie=/sdarticle.pdf

    The biomechanical remodelling process is well formulated for bones and is divided into three stages: (1) bone resorption based on the osteoclast activity, (2) bone deposition based on the osteoblast activity and (3) bone growth control established on RANK/RANKL/OPG pathway-RANKL/OPG balance. The main driving force of remodelling process is a dynamic loading (cyclic compression and expansion, e.g. walking or running), which strongly influences the rate of chemical reactions. The evolution from the omogeneous density distribution to the corticalis and cancellous bone formation is shown. An inevitable influence of a dynamic mechanical loading and osteoprotegerin (OPG) concentration is demonstrated.
    Trvalý link: http://hdl.handle.net/11104/0185684