Počet záznamů: 1

Unusual Interstrand Pt(S,S-diaminocyclohexane)-GG Crosslink Formed by Rearrangement of a Classical Intrastrand Crosslink Within a DNA Duplex

  1. 1.
    0342964 - BC-A 2011 RIV DE eng J - Článek v odborném periodiku
    Kubíček, K. - Monnet, J. - Scintilla, S. - Kopečná, Jana - Arnesano, F. - Trantírek, Lukáš - Chopard, C. - Natile, G. - Kozelka, J.
    Unusual Interstrand Pt(S,S-diaminocyclohexane)-GG Crosslink Formed by Rearrangement of a Classical Intrastrand Crosslink Within a DNA Duplex.
    Chemistry-An Asian Journal. Roč. 5, č. 2 (2010), s. 244-247 ISSN 1861-4728
    Grant ostatní: GA ČR(CZ) GP202/08/P416
    Výzkumný záměr: CEZ:AV0Z60220518
    Klíčová slova: DNA structures * interstrand crosslinks * molecular modeling * NMR spectroscopy * platinum
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 4.188, rok: 2010

    An unusual G6G11 interstrand crosslink is formed by spontaneous rearrangement of the canonical G5G6 intrastrand crosslink generated from the DNA duplex d(CCTTG5G6T7C8TC)-d(G11AGACCAAGG) and Pt(S,S-diaminocyclohexane)2+ (the enantiomer of the antitumor drug oxaliplatin). The final product provides a rare example of intramolecular self-intercalation of DNA.
    Trvalý link: http://hdl.handle.net/11104/0185561