Počet záznamů: 1

Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all?

  1. 1.
    0342950 - BC-A 2011 RIV AU eng J - Článek v odborném periodiku
    Kořený, Luděk - Lukeš, Julius - Oborník, Miroslav
    Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all?.
    International Journal for Parasitology. Roč. 40, č. 2 (2010), s. 149-156 ISSN 0020-7519
    Grant CEP: GA ČR GA206/08/1423; GA ČR GD206/09/H026
    Výzkumný záměr: CEZ:AV0Z60220518
    Klíčová slova: haem synthesis * Kinetoplastida * evolution * horizontal gene transfer * bacterial endosymbiont
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 3.822, rok: 2010

    Kinetoplastid flagellates represent an interesting group of species, as some of them lost the complete pathway of haem synthesis while others possess only the last 3 biosynthetic steps. We decided to supplement a Current view on the phylogeny of these important pathogens with the expected state of haem synthesis in representative species. We propose a scenario in which the ancestor of all trypanosomatids was completely deficient of the synthesis of haem. In trypanosomatids other than members of the genus Trypanosoma, the pathway was partially rescued by genes encoding enzymes for the last three steps, Supposedly obtained by horizontal transfer from a gamma-proteobacterium. This event preceded the diversification of the non-Trypanosoma trypanosomatids. Later, some flagellates acquired a beta-proteobacterial endosymbiont which supplied them with haem precursors. The medically important trypanosomes have remained fully deficient of haem synthesis and obtain this compound from the host.
    Trvalý link: http://hdl.handle.net/11104/0185550