Počet záznamů: 1

New defensins from hard and soft ticks: Similarities, differences, and phylogenetic analyses

  1. 1.
    0342882 - BC-A 2011 RIV NL eng J - Článek v odborném periodiku
    Chrudimská, Tereza - Chrudimský, Tomáš - Golovchenko, Maryna - Rudenko, Natalia - Grubhoffer, Libor
    New defensins from hard and soft ticks: Similarities, differences, and phylogenetic analyses.
    Veterinary Parasitology. Roč. 167, 2/4 (2010), s. 298-303 ISSN 0304-4017
    Grant CEP: GA ČR(CZ) GA524/06/1479; GA ČR GD206/09/H026; GA MŠk(CZ) LC06009
    Výzkumný záměr: CEZ:AV0Z60220518
    Klíčová slova: innate immunity * Ixodidae * Argasidae * defensin
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 2.331, rok: 2010

    Despite the importance of ticks as vectors of disease very little is known about their immune system. Antimicrobial peptides, including defensins (phylogenetically ancient antibacterial peptides) are major components of innate immunity in ticks that have been shown to provide protection against gram-negative and gram-positive bacteria, fungi, viruses and protozoan parasites. With the aim of studying the evolution of the genes involved in tick defense, we identified the preprodefensin genes from four Ornithodoros tick species (O. papillipes: isoforms A, B, and D; O. tartakovskyi and O. puertoricensis: isoforms A and B; O. rostratus: isoform A) and from two Dermacentor tick species (D. reticulatus and D. marginatus: one isoform) not previously described. Phylogenetic analyses revealed that Ornithodoros defensin isoforms (A, B, C, and D) form 4 separate clades, while hard tick defensins are divided into several branches based on particular tick species.
    Trvalý link: http://hdl.handle.net/11104/0185493