Počet záznamů: 1

Nucleotide variability of Ťahyňa virus (Bunyaviridae, Orthobunyavirus) small (S) and medium (M) genomic segments in field strains differing in biological properties

  1. 1.
    0342878 - BC-A 2011 RIV NL eng J - Článek v odborném periodiku
    Kilian, P. - Růžek, Daniel - Danielová, V. - Hypša, Václav - Grubhoffer, Libor
    Nucleotide variability of Ťahyňa virus (Bunyaviridae, Orthobunyavirus) small (S) and medium (M) genomic segments in field strains differing in biological properties.
    Virus Research. Roč. 149, č. 1 (2010), s. 119-123 ISSN 0168-1702
    Grant CEP: GA MŠk(CZ) LC06009
    Výzkumný záměr: CEZ:AV0Z60220518
    Klíčová slova: Tahyna virus * Bunyavirus * california group * genetic variability * virulence
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 2.905, rok: 2010

    Tahyna virus (TAHV), a mosquito-borne bunyavirus (California group), is frequently associated with inapparent or influenza-like (Valtice fever) infections in humans. Field TAHV strains exhibit a high variability in their biological properties with respect to virulence for laboratory mouse, temperature-sensitivity or character of plaques in cell culture. We analyzed complete nucleotide sequences of the small (S) and medium (M) genomic segments of field TAHV strains with different combinations of phenotypic markers. S segment was highly conservative in all analyzed TAHV strains. Within the M segment, the highest variability was observed in the G(C) gene encoding viral envelope protein and to a less extent also in the NSm gene. However, 5' and 3' non-coding regions of M segment, as well as in G(N) gene exhibited highly conservative pattern, indicating its functional importance, but minor or no role in the determination of biological properties of TAHV field strains.
    Trvalý link: http://hdl.handle.net/11104/0185490