Počet záznamů: 1

Characterization of ferritin 2 for the control of tick infestations

  1. 1.
    0342866 - BC-A 2012 RIV GB eng J - Článek v odborném periodiku
    Hajdušek, Ondřej - Almazán, C. - Loosová, Gabriela - Villar, M. - Canales, M. - Grubhoffer, L. - Kopáček, Petr - de la Fuente, J.
    Characterization of ferritin 2 for the control of tick infestations.
    Vaccine. Roč. 28, č. 17 (2010), s. 2993-2998 ISSN 0264-410X
    Grant CEP: GA AV ČR IAA600960910; GA MŠk(CZ) LC06009
    Výzkumný záměr: CEZ:AV0Z60220518
    Klíčová slova: tick ferritin 2 * tick-protective vaccine
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 3.572, rok: 2010

    Tick iron metabolism pathway was targeted in an effort to identify new tick protective antigens. Recombinant Ixodes ricinus (IrFER2) and Rhipicephalus microplus (RmFER2) ferritin 2 proteins were expressed in Escherichia coli and used to immunize rabbits and cattle, respectively. Vaccination with IrFER2 reduced I. ricinus tick numbers, weight and fertility in rabbits with an overall vaccine efficacy (E) of 98%. Control of cattle tick, R. microplus and Rhipicephalus annulatus infestations was obtained in vaccinated cattle with overall E of 64% and 72%, respectively. Notably, the efficacy of the RmFER2 vaccine was similar to that obtained with Bm86 against R. microplus. These collective results demonstrated the feasibility of using ferritin 2 to develop vaccines for the control of tick infestations.
    Trvalý link: http://hdl.handle.net/11104/0185480