Počet záznamů: 1

Interaction of Fluorescently Substituted Metallacarboranes with Cyclodextrins and Phospholipid Bilayers: Fluorescence and Light Scattering Study

  1. 1.
    0342765 - UFCH-W 2011 RIV US eng J - Článek v odborném periodiku
    Uchman, M. - Jurkiewicz, Piotr - Cígler, Petr - Grüner, Bohumír - Hof, Martin - Procházka, K. - Matějíček, P.
    Interaction of Fluorescently Substituted Metallacarboranes with Cyclodextrins and Phospholipid Bilayers: Fluorescence and Light Scattering Study.
    Langmuir. Roč. 26, č. 9 (2010), s. 6268-6275 ISSN 0743-7463
    Grant CEP: GA AV ČR IAAX00320901; GA AV ČR IAA400400621
    Výzkumný záměr: CEZ:AV0Z4040901; CEZ:AV0Z40550506; CEZ:AV0Z40320502
    Klíčová slova: fluorescence * cyclodextrins * phospholipid bilayers
    Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
    Impakt faktor: 4.269, rok: 2010

    We prepared two fluorescein-[3-cobalt(III) bis(1,2-dicarbollide)](-) conjugates. They are sparingly soluble in water and form large aggregates in aqueous solutions. An extensive study on their spectral and aggregation behavior was carried out. To prepare their well-defined dispersion in aqueous systems, we studied the interaction of both probes with two biocompatible amphiphilic systems, cyclodextrins, which are frequently used in drug-delivery systems, and phospholipid membranes, which are the major constituents of cell barriers in living organisms. The presence of fluorescein in both conjugates allows us to study their behavior in detail by steady-state and time-resolved fluorometry, fluorescence correlation spectroscopy, and fluorescence lifetime imaging. The self-assembly of these metallacarboranes in aqueous solutions was studied by dynamic light scattering.
    Trvalý link: http://hdl.handle.net/11104/0005889