Počet záznamů: 1

Determination of the level of DNA modification with cisplatin by catalytic hydrogen evolution at mercury-based electrodes

  1. 1.
    0342607 - BFU-R 2011 RIV US eng J - Článek v odborném periodiku
    Horáková Brázdilová, Petra - Těsnohlídková, Lucie - Havran, Luděk - Vidláková, Pavlína - Pivoňková, Hana - Fojta, Miroslav
    Determination of the level of DNA modification with cisplatin by catalytic hydrogen evolution at mercury-based electrodes.
    Analytical Chemistry. Roč. 82, č. 7 (2010), s. 2969-2976 ISSN 0003-2700
    Grant CEP: GA ČR(CZ) GP204/07/P476; GA AV ČR(CZ) IAA500040701; GA AV ČR(CZ) 1QS500040581; GA MŠk(CZ) LC06035
    Grant ostatní:GA AV ČR(CZ) IAA400040903
    Program:IA
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: cisplatin * electrochemical analysis of DNA * mercury electrode
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 5.874, rok: 2010

    In this paper we used voltammetry at the mercury-based electrodes for the monitoring of DNA modification with cisdiamminedichloroplatinum (cisplatin), a representative of metallodrugs used in the treatment of various types of cancer or being developed for such purpose. Application of the electrochemical technique in studies of DNA reactivity with various anticancer platinum compounds, as well as for an easy determination of the extent of DNA platination in studies of its biochemical effects, is discussed.
    Trvalý link: http://hdl.handle.net/11104/0185298