Počet záznamů: 1

Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position

  1. 1.
    0342431 - UOCHB-X 2011 RIV GB eng J - Článek v odborném periodiku
    Krečmerová, Marcela - Masojídková, Milena - Holý, Antonín
    Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position.
    Bioorganic & Medicinal Chemistry. Roč. 18, č. 1 (2010), s. 387-395 ISSN 0968-0896
    Grant CEP: GA MŠk 1M0508; GA AV ČR 1QS400550501
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: 5-azacytosine * acyclic nucleoside phosphonates * antivirals * orthoesters * condensation
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.978, rok: 2010

    A series of 6-alkyl derivatives of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine (HPMP-5-azaC) was prepared using ammonia mediated ring-opening reaction of diisopropyl esters of HPMP-5-azaC to a corresponding carbamoylguanidine derivative followed by ring-closure reaction with orthoesters.
    Trvalý link: http://hdl.handle.net/11104/0185170