Počet záznamů: 1

New coupling strategy for radionuclide labeling of synthetic polymers

  1. 1.
    0342352 - UMCH-V 2011 RIV GB eng J - Článek v odborném periodiku
    Hrubý, Martin - Kučka, Jan - Nováková, Michaela - Macková, Hana - Vetrík, Miroslav
    New coupling strategy for radionuclide labeling of synthetic polymers.
    Applied Radiation and Isotopes. Roč. 68, č. 2 (2010), s. 334-339 ISSN 0969-8043
    Grant CEP: GA AV ČR KAN200200651; GA ČR GA202/09/2078; GA MŠk 1M0505
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: polymer * radionuclide * labeling
    Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
    Impakt faktor: 0.999, rok: 2010

    We have developed a radiolabeling strategy for synthetic polymers based on the formation of azo dye usable for both covalent and chelating labeling modalities under mild conditions. Poly[N-(2-hydroxypropyl)methacrylamide] and poly(N-isopropyl acrylamide) were used as model polymers. N-methacryloyl tyrosinamide was introduced into the polymers and the phenolic moiety was then reacted with diazotized chelator precursors. The conjugates were radiolabeled with both the covalently bound (iodine-125) and chelated (indium-111) radionuclides in high yields and sufficient in vitro stability of the labels was proven.
    Trvalý link: http://hdl.handle.net/11104/0005864